ABSTRACT
Introduction: Acute coagulopathy, specific placental change, and fetal death are reported in pregnant women with COVID-19;however, the pathogenesis of them remains unknown. We report two cases of stillbirth in pregnant women with COVID-19 who showed acute coagulopathy and their placentas showed characteristic pathological findings due to COVID-19. Case: Case 1: A 28-year-old pregnant woman (gravida 3, para 2) who had undergone two cesarean sections had a fever of 39 degree and was positive for SARS-CoV-2 at 26 weeks of gestation. She showed thrombocytopenia and subsequent coagulopathy on day 7, and her fetus was dead on day 9. She underwent a cesarean section after blood transfusion and her coagulability thereafter improved. Case 2: A 35-year-old pregnant woman (gravida 3, para 2) who had no symptoms was positive for SARS-CoV-2 at 20 weeks of gestation. She also presented with thrombocytopenia on day 5. Her fetus was dead, and she went into labor spontaneously and virginally delivered a stillborn baby on day 9. Her coagulability thereafter returned to normal. Placental histology of both cases showed intervillous infiltration of histiocytes, necrosis of trophoblast, and fibrin deposition, and the expression of SARS-CoV-2 spike protein was observed in the syncytiotrophoblasts of the villi. Discussion(s): Specific placental changes related to COVID-19 are thought to be the result of an immune response rather than direct infection with SARS-CoV-2. The placental changes induced by COVID-19 might have caused fetal death. When managing pregnant women with COVID-19, thrombopenia may be a predictive marker of fetal death following placental inflammatory changes. Copyright © 2022
ABSTRACT
The purpose of this study is to analyze how the condition of the stock price of Companies in the Pharmaceutical Sector listed on the stock exchange before and during covid 19 (2019-2020). This Research method uses descriptive research with a quantitative approach, and the method of purposive sampling in taking the sample so obtained 9 companies that meet the criteria that have been determined from a total of 12 populations of a company in the pharmaceutical sector which are listed in BEI. The type and source of data used in this research is secondary data, obtained from the web finance.yahoo.com. This study contains the results of the analysis chart of stock price movements with the use of moving average 20, 50, 100 and Tables by using the close price for the average of any month on any company for 2 years i.e., 2019 and 2020. The results of this study show that the movement of the stock price on the 2019 show buy and sell signals are stable although there are some conditions where the shares of each company is experiencing an uptrend or a downtrend but the decline and rise in the year 2019 still difase reasonable because it is not too significant, but when the pandemic covid-19 (2020) the average movement of the stock prices of companies in the pharmaceutical sector the beginning to the end of the year from 9 companies in the pharmaceutical sector are all increased due to an increase in demand for products in the field of health is very influential, both on the revenue and profit of the company itself or increase in investor interest in shares of the pharmaceutical sector. © 2021. RIGEO. All Rights Reserved.